The “nocebo effect” in drug hypersensitivity diagnosis

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چکیده

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The "nocebo effect" in drug hypersensitivity diagnosis

Background Placebo-controlled oral drug provocation tests (DPTs) are an important step in drug hypersensitivity diagnosis. Administration of placebo (an inert sostance not detectable from drug) is recommended to avoid psychological influences on the interpretation of DPT results, however actually little is known about how to deal a reaction to placebo and how to go further with the diagnostic p...

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Diagnosis and management of drug hypersensitivity reactions.

The present article addresses the advances in the diagnosis and management of drug hypersensitivity reactions that were discussed in the 4th Drug Hypersensitivity Meeting held in Rome in April 2010. Such reactions can be classified as immediate or nonimmediate according to the time interval between the last drug administration and onset. Immediate reactions occur within 1 hour, and nonimmediate...

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Determinants of nocebo effect during oral drug provocation tests.

BACKGROUND A "nocebo" effect is defined as troublesome symptoms after the administration of placebo. The aim of this study was to determine characteristics of nocebo responses and related factors. METHODS Patients with a reliable history of drug-induced hypersensitivity reactions subjected to placebo-controlled oral drug provocation tests and reacted to placebo, were consecutively included in...

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The nocebo effect of drugs

While the placebo effect has been studied for a long time, much less is known about its negative counterpart, named the nocebo effect. However, it may be of particular importance because of its impact on the treatment outcomes and public health. We conducted a review on the nocebo effect using PubMed and other databases up to July 2014. The nocebo effect refers by definition to the induction or...

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ژورنال

عنوان ژورنال: Clinical and Translational Allergy

سال: 2014

ISSN: 2045-7022,2045-7022

DOI: 10.1186/2045-7022-4-s3-o9